HCID 20376598, compound → HCID 20376640, compound

Participants

Reaction Steps

To a heated mixture containing 13.5 g (0.045 mole) of the amide prepared as in (b) above in 250 ml of 5% acetic acid was added portionwise and with stirring 12 g of iron powder. The mixture was refluxed for 1/2 hour. The mixture was filtered while hot and the cooled filtrate was extracted with ether. The ether extract was washed with aqueous sodium bicarbonate, dried, concentrated and recrystallized from ether-hexane (1:2) to give 10.1 g (83%) of product as a colorless solid; m.p. 140°-142° C.

Provenance & Evidence