Ethanol → 2,3,5,10,11,11 a-hexahydro-11-ethoxy-9-hydroxy-8-methyl-1H-pyrrolo[2,1-C][1,4]benzodiazepin-5-one

Participants

Reaction Conditions

Reaction Steps

350 mg of 6,8,9,10,10a ,11-hexahydro-3-methyl-1-phenyl-1H-oxazolo[ 5,4,3-jk]pyrrolo[2,1-C][1,4]benzodiazepin-6,11-dione was treated in the same manner as in Example 4. The concentrate of the chloroform layer obtained was dissolved in 2 ml of hot ethanol, cooled to -20° C., and allowed to stand at this temperature for 3 days. Thus, 86 mg of 2,3,5,10,11,11 a-hexahydro-11-ethoxy-9-hydroxy-8-methyl-1H-pyrrolo[2,1-C][1,4]benzodiazepin-5-one was obtained in a colorless crystalline form. Recrystallization of the resulting product from ethanol gave a colorless needle-like crystal having a melting point of 155° to 157° C.

Provenance & Evidence