Ethanol → HCID 21205052, compound

Participants

Reaction Conditions

Reaction Steps

147 g of isatin and 720 g of α-naphthol are brought together and initially heated to 100° C. Hydrogen chloride gas dried over sulphuric acid is then passed in, during which the temperature rises to 150° C. After the exothermic reaction has subsided the reaction temperature is maintained at 115° C. for a further 5 hours and after cooling, 1,000 ml of ethanol are added to the solidified crystal mass. The crystals, freed from excess phenol, are filtered off and dried. 334 g (80% yield) of colorless crystals are obtained from chloroform/acetone. Melting point 300° C., with decomposition.

Provenance & Evidence