HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(Thiazol-2-yl)methylthio]ethylamine → 3-[2-(2-Thiazolylmethylthio)ethylamino]-6-(3-methoxybenzyl)-1,2,4-triazin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(Thiazol-2-yl)methylthio]ethylamine | HCID 12923403 | — |
| Reactant | 3-Methylthio-6-(3-methoxybenzyl)-1,2,4-triazin-5-one | HCID 135624292 | — |
| Product | 3-[2-(2-Thiazolylmethylthio)ethylamino]-6-(3-methoxybenzyl)-1,2,4-triazin-5-one | HCID 135703224 | 50.4% |
Reaction Steps
3-Methylthio-6-(3-methoxybenzyl)-1,2,4-triazin-5-one (1.18 g) and 2-(2-thiazolylmethylthio)ethylamine (0.87 g) were heated together on an oil bath (160°-70° ) for 3/4 hour. The resulting oil, after chromatography and crystallisation from ethanol, gave the title compound as a colourless solid (0.88 g) m.p. 128°-29°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04185103 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-63d48cc2bde4489fa729c55e5ca7579d |
| Source note | uspto-grants-1980_01 |