4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → 3-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-6-(3-pyridylmethyl)-1,2,4-triazin-5-one

Participants

Reaction Steps

3-Methylthio-6-(3-pyridylmethyl)-1,2,4-triazin-5-one (2.34 g) and 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (1.88 g) were heated together on an oil bath (160°-70° ). The cooled mixture was triturated with boiling methanol and the solid was recrystallised from dimethylformamide to give the title compound as a colourless solid (2.53 g) m.p. 232°-233°.

Provenance & Evidence