Bromine → HCID 13340372, compound

Participants

Reaction Steps

To a stirred suspension of 2.40 gm of N-(2-amino-benzyl)-S-methyl-cysteine in 50 cm3 anhydrous methanol a solution of 0.52 cc of bromine in 20 cc of methanol was added dropwise. After the addition of bromine was finished, stirring was continued for 2 hours. The solvent was evaporated in vacuo on a water bath, and residue was dissolved in 50 cc of distilled water. The aqueous solution was decolored by refluxing for 1 hour in the presence of a small quantity of charcoal. The coal was removed by filtration, and the pH of the filtrate was adjusted to 5 by addition of dilute ammonia. The desired product precipitated out. The mixture was allowed to stand for several hours, whereupon the precipitate was centrifuged off, washed with water and dried in a drying chamber. Melting point: 228° C.

Provenance & Evidence