HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-({[4-(Benzyloxy)phenyl]methyl}amino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 4-({[4-(benzyloxy)phenyl]methyl}amino)benzoate | HCID 13079673 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 4-({[4-(Benzyloxy)phenyl]methyl}amino)benzoic acid | HCID 13079672 | — |
Reaction Steps
A mixture of 10 g. of ethyl p-[p-(benzyloxy)benzylamino]benzoate (prepared as described in Example 11) 10 g. of potassium hydroxide and 200 ml. of ethanol-water (9:1) are refluxed for 4.5 hours. While hot, the mixture is acidified with concentrated hydrochloric acid. Dilution with water and filtration gives tan crystals which are recrystallized from glacial acetic acid to give off-white crystals, m.p. 206°-208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04185115 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-c8ad0d790e8f408a9a811561f269b2d0 |
| Source note | uspto-grants-1980_01 |