HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[(7-Phenylheptyl)amino]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 4-[(7-phenylheptyl)amino]benzoate | HCID 13079667 | — |
| Reactant | Water ethanol | HCID 19096565 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-[(7-Phenylheptyl)amino]benzoic acid | HCID 13079666 | — |
Reaction Steps
A mixture of 5 g. of ethyl p-[(7-phenylheptyl)amino]benzoate (prepared as described in Example 34), 5 g. of KOH and 50 ml. of ethanol-water (9:1) is refluxed for 3.5 hours. The mixture is acidified while hot with concentrated hydrochloric acid, diluted with H2O, chilled and filtered. The solid is washed with H2O to give off-white crystals, m.p. 123°-126° C. Recrystallization from ethanol gives tan crystals, m.p. 123.5°-125° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04185115 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-3cdf21e544b5494f9280a93b2850a555 |
| Source note | uspto-grants-1980_01 |