Hydrochloric Acid → Sulfuric acid--6-(morpholin-4-yl)pyrimidine-2,4,5-triamine (1/1)

Participants

Reaction Conditions

Reaction Steps

2.5 gm of 2,4-diamino-6-morpholino-5-nitroso-pyrimidine was suspended in 15 ml of water, and 2 N HCl (5 ml) was added until the substance just dissolved. The mixture was heated to 50° C.; and sodium dithionite (Na2S2O4) was added until the violet color solution took on a yellow color. Then, the solution was filtered, cooled, and adjusted to a pH 2 by means of sulfuric acid (1:1). After a short time, the pyrimidine derivative precipitated as pyrimidine sulfate; the yield was 2.6 gm which was 76.4% of theory.

Provenance & Evidence