HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(tert.-Butylamino)-3-[(1-phenyl-5-tetrazolyl)oxy]-2-propanol Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 1-(1-Phenyltetrazol-5-yloxy)-2,3-epoxypropane | HCID 12399823 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1-(tert.-Butylamino)-3-[(1-phenyl-5-tetrazolyl)oxy]-2-propanol Hydrochloride | HCID 12399832 | — |
Reaction Steps
2,3-Epoxy-1-[(1-phenyl-5-tetrazolyl)-oxy]propane (43.7 g., 0.20 mole) was heated at the reflux temperature in 150 ml. of tert.-butylamine and 300 ml. of benzene for 9 hours. The solvents were evaporated in vacuo and the residual oil was dissolved in 100 ml. of EtOH and acidified with ethanolic HCl. Dilution with diethyl ether gave 44.8 g. of the hydrochloride of the product, m.p. 73°-82°. Recrystallization from i-PrOH-IPE gave 30.8 g., m.p. 152.5°-154.5° (corr.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04186131 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-14a3d25c9fc94508a9d4e3ed294674ac |
| Source note | uspto-grants-1980_01 |