HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-Acetyl-5-(3,4-dimethoxyphenyl)-2-oxazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 5-(3,4-Dimethoxyphenyl)-4,5-dihydro-1,3-oxazol-2-ol | HCID 3050661 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-Acetyl-5-(3,4-dimethoxyphenyl)-2-oxazolidinone | HCID 20376217 | 73% |
Reaction Steps
8.9 mmol of 5-(3,4-dimethoxyphenyl)-2-oxazolidinone is combined with 10 ml. of acetic anhydride and 5 ml. of pyridine and heated for 5 hours to 100°. After concentrating the reaction mixture, it is recrystallized from ethyl acetate, thus obtaining 3-acetyl-5-(3,4-dimethoxyphenyl)-2-oxazolidinone in a 73% yield, m.p. 175°-182°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04186129 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-97ea86f2edc5482ea8e366bc7dbf8b27 |
| Source note | uspto-grants-1980_01 |