Dimethylamine → HCID 19373598, compound

Participants

Reaction Steps

228.3 g (1.0 mole) of 2-hydroxy-4-methoxy-benzophenone, 146.3 (1.3 moles, 40% aqueous solution) of dimethylamine, 105.4 g (1.3 moles, 37% aqueous solution) of formalin and 1200 ml of methanol was put into a flask, dissolved and heated under stirring at reflux temperature (68° to 70° C.) for 6 hours. When solvent was vacuum distilled off, 285 gr of 5-dimethylaminomethyl-2-hydroxy-4-methoxybenzophenone was obtained. The product had m.p. 69° C., infrared absorption at 1620 (Carbonyl), 2760 and 2800 (N--CH group) wave numbers, and neutralization equivalent (as nitrogen) 4.89% (Calculated 4.91%). The NMR spectrum provided evidence for the 5-position of the dimethylaminomethyl group.

Provenance & Evidence