HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminomethyl-1-ethylpyrrolidine → N-(1-ethyl-2-pyrrolidylmethyl)-7-ethylsulfonyl-1,4-benzodioxane-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| Reactant | 7-Ethylsulfonyl-1,4-benzodioxane-5-carbonyl chloride | HCID 20544728 | — |
| Product | N-(1-ethyl-2-pyrrolidylmethyl)-7-ethylsulfonyl-1,4-benzodioxane-5-carboxamide | HCID 20293650 | 69.8% |
Reaction Steps
In a similar manner 64.5 g of dextrorotary-1-ethyl-2-aminomethylpyrrolidine was reacted with 146 g of 7-ethylsulfonyl-1,4-benzodioxane-5-carbonyl chloride to give, after treatment and purification, 133.5 g of dextrorotatory N-(1-ethyl-2-pyrrolidylmethyl)-7-ethylsulfonyl-1,4-benzodioxane-5-carboxamide (M.P.: 111°-122° C.; yield: 69.8%); (α)D20 =55.5° (in 5% solution in dimethylformamide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04186135 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-5d47c229ba6e4abcaa8e59a7ae91f3ce |
| Source note | uspto-grants-1980_01 |