HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Allyl)pyrrolidine-2-methylamine → N-(1-allyl-2-pyrrolidylmethyl)-7-methylsulfamoyl-1,4-benzodioxane-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Allyl)pyrrolidine-2-methylamine | HCID 117296 | — |
| Reactant | 7-Methylsulfamoyl-1,4-benzodioxane-5-carbonyl chloride | HCID 20544720 | — |
| Product | N-(1-allyl-2-pyrrolidylmethyl)-7-methylsulfamoyl-1,4-benzodioxane-5-carboxamide | HCID 24834937 | 52.6% |
Reaction Steps
In a similar manner to the above example, 84 g of dextrorotatory 1-allyl-2-aminomethyl-pyrrolidine was reacted with 175 g of 7-methylsulfamoyl-1,4-benzodioxane-5-carbonyl chloride to give, after purification, 125 g of dextrorotatory-N-(1-allyl-2-pyrrolidylmethyl)-7-methylsulfamoyl-1,4-benzodioxane-5-carboxamide (M.P.: 104°-105° C.; yield: 52.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04186135 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-6717da927fbf4648b1fc162dba139651 |
| Source note | uspto-grants-1980_01 |