HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl-8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 8-Methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid | HCID 20544690 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl-8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylate | HCID 20544706 | 96.5% |
Reaction Steps
396 g of methanol were introduced into a balloon flask provided with a condenser and then 51 g of sulfuric acid and 114.5 g of 8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid were added while cooling. The mixture was heated under reflux and then poured into 485 cm3 of water and 40 g of sodium carbonate. The precipitate was dried off, washed and dried. 110.5 g of methyl-8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylate were obtained (M.P.: 202°-203° C.; yield: 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04186135 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-4a2638ed94394d4b81c6963fd254a900 |
| Source note | uspto-grants-1980_01 |