HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 6,7-Dibromo-8-nitro-1,4-benzodioxane-5-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6,7-Dibromo-8-nitro-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid | HCID 20544759 | — |
| Product | 6,7-Dibromo-8-nitro-1,4-benzodioxane-5-carbonyl chloride | HCID 20544755 | 91% |
Reaction Steps
96 g of 6,7-dibromo-8-nitro-1,4-benzodioxane-5-carboxylic acid and 200 ml of thionyl chloride were introduced into a balloon flask provided with an agitator and a thermometer. The mixture was heated under reflux and then the excess thionyl chloride was removed under vacuum. The residue was dissolved in 100 ml of isopropyl ether and then the solvent removed and the product air-dried. 91 g of 6,7-dibromo-8-nitro-1,4-benzodioxane-5-carbonyl chloride were obtained (M.P.: 215° C.; yield: 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04186135 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-e8cc087864b94f9ab11a4ee400f42bd2 |
| Source note | uspto-grants-1980_01 |