HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(1-ethyl-2-pyrrolidylmethyl)-8-amino-1,4-benzodioxane-5-carboxamide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| Reactant | 8-Amino-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid | HCID 21193470 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(1-ethyl-2-pyrrolidylmethyl)-8-amino-1,4-benzodioxane-5-carboxamide dihydrochloride | HCID 70548321 | 72.7% |
Reaction Steps
According to the method described in Example 2, 42 g of 8-amino-1,4-benzodioxane-5-carboxylic acid were treated with methanol and the resulting compound treated with 33 g of 1-ethyl-2-aminomethylpyrrolidine and then with a solution of 13 g of hydrochloric acid in absolute alcohol. 49 g of N-(1-ethyl-2-pyrrolidylmethyl)-8-amino-1,4-benzodioxane-5-carboxamide dihydrochloride were obtained (M.P.: 173° C.; yield: 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04186135 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-0629b08b1ad14ab99227c2acf11f180e |
| Source note | uspto-grants-1980_01 |