Sodium Sulfate → HCID 13020118, compound

Participants

Reaction Steps

The base (9.5 g, 0.027 moles) from ethyl 3-(4-bromophenyl)-3-hydroxy-3-(3-pyridyl)propanoate hydrochloride (step 1) was prepared and dissolved in ethyl ether (50 ml). This solution was added dropwise to an ice-cold mixture of lithium aluminum hydride (1.0 g, 0.027 moles) and ethyl ether (150 ml). The reaction mixture was refluxed for 5 hours, cooled and a saturated sodium sulphate solution was added until a white precipitate was formed. This was filtered off and the filtrate evaporated. The residue was crystallized from chloroform. 1-(4-bromophenyl)-1-(3-pyridyl)-1,3-propanediol was obtained. Yield: 39%. M.p. 130°-132° C.

Provenance & Evidence