Hydrochloric Acid → HCID 12519121, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 13.7 g of 5-chloro-1-(2-nitrophenyl)indoline and 0.25 g of 1% Pt on C in 250 ml absolute ethanol is shaken at 50 psi of H2 until the theoretical amount of H2 is taken up. The mixture is filtered and the solvent removed at 50° C. to leave the product base as an oil. This is dissolved in 200 ml of ether, cooled to 0° C., and treated with gaseous HCl to precipitate 1-(2-aminophenyl)-5-chloroindoline hydrochloride, m.p. 235°-238° C. dec.

Provenance & Evidence