Phosphorus oxychloride → HCID 12519138, compound

Participants

Reaction Steps

A rapidly stirred solution of 52.65 g of 1-[2-(3-phenyl-1-oxo-propyl)aminophenyl]indoline in 200 ml POCl3 under N2 is slowly brought to 105°-115° C. After 9.5 hours, the mixture is permitted to cool to room temperature for over 48 hours. The excess POCl3 is distilled at aspirator pressure (bath temperature 55°-60° C.) to yield a solid which is triturated with hexane, filtered, washed with additional hexane, and dried at room temperature under high vacuum to yield 1,2-dihydro-6-(2-phenylethyl)-indolo[1,7-ab][1,5]benzodiazepine hydrochloride, m.p. 181.5°-183.0° C.

Provenance & Evidence