Water → HCID 12519156, compound

Participants

Reaction Steps

To a well stirred mixture of 45.0 g of 4-chloro-6-methyl-1,2-dihydroindolo[1,7-ab][1,5]benzodiazepine hydrochloride, in 450 ml of absolute ethanol, cooled to 0° C. under N2, is added sodium borohydride in portions until the initial purple color is discharged. The mixture is stirred 1 hour longer at 0° C., then 2 hours at room temperature. Then water is added in portions to destroy excess reagent and to maximize precipitation of product. The latter is filtered, washed well with water and dried to yield 4-chloro-6-methyl-1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepine, m.p. 167°-170° C.

Provenance & Evidence