反应详情

温度

0 °C

A stirred mixture, under N2, of 23.0 g of 1,2-dihydro-6-phenylindolo[1,7-ab][1,5]benzodiazepine in 200 ml of absolute ethanol is cooled to 0°-5° C. Sodium borohydride is then added in small portions and at such a rate as to keep the reaction temperature less than 5° C., and to minimize foaming. About 3 g. are required to discharge the initial blue-purple color, and another 1 g. is added to insure complete reduction. The mixture is then stirred 1 hour at 0° C. and 1 hour at room temperature. Water is added, the product is filtered, washed repeatedly with water, and dried to give 6-phenyl-1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepine, m.p. 161°-164° C.

1. customthe reaction temperature less than 5° C.
2. additionis added
3. filtrationthe product is filtered
4. washwashed repeatedly with water
5. customdried