Sodium borohydride → HCID 20376337, compound

Participants

Reaction Conditions

Reaction Steps

An ice cold solution of 8.88 g of 1,2-dihydro-6-furylindolo[1,7-ab][1,5]benzodiazepine (HCl salt) in 100 ml 3:1 absolute ethanol-THF is treated portionwise with 2.5 g NaBH4 added at such a rate as to minimize foaming. After stirring for 1.5 hours at 0° C., water is added dropwise and the product is partitioned in CH2Cl2 -water. The aqueous phase is extracted with CH2Cl2 and the combined organic portions are washed with brine, dried over K2CO3, and concentrated to an oil which solidifies upon standing to yield 6-furyl-1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepine, m.p. 141°-144° C.

Provenance & Evidence