Carbon Dioxide → 5-Fluorouracil

Participants

Reaction Conditions

Reaction Steps

In the example, 20 g of crystals of 5-fluoro-orotic acid monohydrate obtained by the fluorination and the post-treatment of Example 1 was suspended in 80 ml of triethyleneglycol dimethyl ether and the mixture was heated under stirring whereby water was generated at higher than 130° C. and carbon dioxide was generated at higher than 190° C. The decarboxylation was completed by heating at 200° C. for about 20 minutes. After cooling the reaction mixture, the reaction product was separated by a filtration and recrystallized from water to obtain 12.2 g of 5-fluorouracil. The yield was 90% based on 5-fluoro-orotic acid monohydrate.

Provenance & Evidence