HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2052724Generated: November 2, 2026
5-Fluoroorotic acid monohydrate → 5-Fluorouracil
https://huagongshe.com/reaction/2052724
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Fluoroorotic acid monohydrate | HCID 16212749 | — |
| Reactant | 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid monohydrate | HCID 16218504 | — |
| Product | 5-Fluorouracil | HCID 3385 | — |
Reaction Steps
In the reaction, the conversion of the orotic acid monohydrate was 100% and the yield of 5-fluoro-orotic acid monohydrate was 85.0%. The crystals were heated at 260° C. under a reduced pressure of lower than 1 mmHg to perform the decarboxylation to obtain 22.5 g of 5-fluorouracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04186266 |
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| Source dataset | uspto-grants-1980_01 |
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| ORD ID | ord-efbca071b4d343cf9aff19e00611d2dd |
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| Source note | uspto-grants-1980_01 |
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