反应详情

温度

50 °C

The alcohol compound (195 mg, 0.981 mmol) obtained in Step 1-3 was dissolved in chloroform (5 ml). Activated manganese dioxide (1.27 g) was added to the obtained solution, and they were violently stirred at 50° C. for 2 hours. After leaving to cool, manganese dioxide was filtered out, and the filtrate was concentrated under reduced pressure. After the purification by the silica gel column chromatography, 2-chloro-4-t-butylbenzaldehyde (yield: 152 mg, 79%) was obtained.

1. customAfter leaving
2. temperatureto cool
3. filtrationmanganese dioxide was filtered out
4. concentrationthe filtrate was concentrated under reduced pressure
5. customAfter the purification by the silica gel column chromatography