HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2052802Generated: October 31, 2026
Phosphorus oxychloride → Methyl 1-chloroisoquinoline-4-carboxylate
https://huagongshe.com/reaction/2052802
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Methyl 1-Oxo-2H-Isoquinoline-4-Carboxylate | HCID 641184 | — |
| Product | Methyl 1-chloroisoquinoline-4-carboxylate | HCID 3338790 | — |
Reaction Steps
A mixture of the product from part 3 (12.5 g) in 50 ml of POCl3 is stirred at 100° C. for about two hours then cooled and concentrated under vacuum. The residue is dissolved in 300 ml of CHCl3, and the resulting solution is washed with aqueous NaHCO3 and water, dried over Na2SO4, filtered and then concentrated to give the title compound, m.p. 53-55° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07326709B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-1cea6c6c0ecb4a04851aa14fd91db448 |
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| Source note | uspto-grants-2008_02 |
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