反应详情

To a solution of 6,7-dimethoxy-4-piperazino-9H-pyrimido[4,5-b]indole (200 mg, 0.64 mmol) and pyridine (0.5 mL, 6.4 mmol) in dichloromethane (20 mL) was added the solution of product 1c in dichloromethane (20 mL) and the mixture was stirred overnight. Methanol was added to quench excess thiophosgene, and the residue after removal of solvent was purified by silica gel column chromatography eluting with 5% methanol/dichloromethane and further recrystallized from dichloromethane/hexane to give 130 mg (40%).

1. customto quench excess thiophosgene
2. customthe residue after removal of solvent
3. customwas purified by silica gel column chromatography
4. washeluting with 5% methanol/dichloromethane
5. customfurther recrystallized from dichloromethane/hexane
6. customto give 130 mg (40%)