Hydrochloric Acid → HCID 178508605, compound

Participants

Reaction Steps

0.1 g (0.23 mmol) of cis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester are dissolved in 1.8 ml of THF/1 M LiOH (1:1, v/v). After stirring at RT for 15 min, the pH of the solution is adjusted to pH=6 with 2N HCl and cis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid is obtained by filtering the suspension. Analytical HPLC: tR=6.61 min (Grad 2); ES-MS: m/eo=415.0.

Provenance & Evidence