2-Methoxyethyl chloroformate → HCID 178496346, compound

HRID 2052994Notes

Reaction equation

HRID 2052994 reaction equation
[NH2:1][CH2:2][C@@H:3]1[CH2:6][C@H:5]([N:7]2[C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH2:16])[C:10]=3[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:18]=3)=[CH:8]2)[CH2:4]1.Cl[C:32]([O:34][CH2:35][CH2:36][O:37][CH3:38])=[O:33]>>[CH3:38][O:37][CH2:36][CH2:35][O:34][C:32](=[O:33])[NH:1][CH2:2][C@H:3]1[CH2:4][C@@H:5]([N:7]2[C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH2:16])[C:10]=3[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:18]=3)=[CH:8]2)[CH2:6]1

Participants

3

Reactant 2

HCID 694002-Methoxyethyl chloroformateHCID 178511294HCID 178511294, compound

Product 1

HCID 178496346HCID 178496346, compound

Procedure

cis-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-carbamic acid 2-methoxy-ethyl ester is prepared as described in Example 22 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and 2-methoxyethyl chloroformate (TCI America, Portland, Oreg., U.S.A.). Analytical HPLC: tR=7.02 min (Grad 2); ES-MS: m/eo=502.0.

Sources & evidence

ORD record
ord-1c458bb99b544966861d805d2c568840
Source dataset
uspto-grants-2008_02
Patent number
US07326699B2

Reaction notes

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