tert-Butyl isocyanate → HCID 178449594, compound

HRID 2052999Notes

Reaction equation

HRID 2052999 reaction equation
[NH2:1][CH2:2][C@@H:3]1[CH2:6][C@H:5]([N:7]2[C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH2:16])[C:10]=3[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:18]=3)=[CH:8]2)[CH2:4]1.[C:31]([N:35]=[C:36]=[O:37])([CH3:34])([CH3:33])[CH3:32]>>[NH2:16][C:15]1[C:10]2[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:18]=3)=[CH:8][N:7]([C@@H:5]3[CH2:4][C@H:3]([CH2:2][NH:1][C:36]([NH:35][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:37])[CH2:6]3)[C:11]=2[N:12]=[CH:13][N:14]=1

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 178511294HCID 178511294, compound

Product 1

HCID 178449594HCID 178449594, compound

Procedure

cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-tert-butyl-urea is prepared as described in Example 26 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and tert-butyl isocyanate (Fluka, Buchs, Switzerland). Analytical HPLC: tR=6.61 min (Grad 2); ES-MS: m/eo=499.0.

Sources & evidence

ORD record
ord-5bd5afdd35b4486eb17bc63f32e90e79
Source dataset
uspto-grants-2008_02
Patent number
US07326699B2

Reaction notes

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