Isocyanic acid, p-methoxybenzyl- → HCID 178491218, compound

HRID 2053001Notes

Reaction equation

HRID 2053001 reaction equation
[NH2:1][CH2:2][C@@H:3]1[CH2:6][C@H:5]([N:7]2[C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH2:16])[C:10]=3[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:18]=3)=[CH:8]2)[CH2:4]1.[CH3:31][O:32][C:33]1[CH:42]=[CH:41][C:36]([CH2:37][N:38]=[C:39]=[O:40])=[CH:35][CH:34]=1>>[NH2:16][C:15]1[C:10]2[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:18]=3)=[CH:8][N:7]([C@@H:5]3[CH2:4][C@H:3]([CH2:2][NH:1][C:39]([NH:38][CH2:37][C:36]4[CH:41]=[CH:42][C:33]([O:32][CH3:31])=[CH:34][CH:35]=4)=[O:40])[CH2:6]3)[C:11]=2[N:12]=[CH:13][N:14]=1

Participants

3

Reactant 2

HCID 187910Isocyanic acid, p-methoxybenzyl-HCID 178511294HCID 178511294, compound

Product 1

HCID 178491218HCID 178491218, compound

Procedure

cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(4-methoxy-benzyl)-urea is prepared as described in Example 26 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and 4-methoxybenzyl isocyanate (Aldrich, Buchs, Switzerland). Analytical HPLC: tR=7.21 min (Grad 2); ES-MS: m/eo=562.9.

Sources & evidence

ORD record
ord-0074ef2b6573486a8fc17da64aedbf17
Source dataset
uspto-grants-2008_02
Patent number
US07326699B2

Reaction notes

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