Potassium cyanate → HCID 178514100, compound

Participants

Reaction Steps

To a solution of 50 mg (0.125 mmol) of trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine in 5 ml of methanol is added 45 mg (0.561 mmol) of potassium cyanate (Aldrich, Buchs, Switzerland). The mixture is refluxed for one week. After concentration to dryness, the residue is purified by flash-chromatography (dichloromethane:methanol=9:1) to provide trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-urea. Analytical HPLC: tR=6.43 min (Grad 2); ES-MS: m/eo=443.0.

Provenance & Evidence