Chloroacetyl chloride → HCID 178508600, compound

Participants

Reaction Steps

To a suspension of 210 mg (0.53 mmol) of trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine in 10 ml of acetonitrile is added 49 μl (0.61 mmol) of chloro-acetyl chloride (Fluka, Buchs, Switzerland) and 85 μl (0.61 mmol) of triethylamine. The solution is stirred for 5 h at RT. trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-chloro-acetamide is obtained after purification of the crude mixture by medium-pressure liquid chromatography. Analytical HPLC: tR=6.94 min (Grad 2); ES-MS: m/eo=476.0.

Provenance & Evidence