Methyl Isocyanate → HCID 178485928, compound

HRID 2053012Notes

Reaction equation

[NH2:1][CH2:2][C@@H:3]1[CH2:6][C@H:5]([N:7]2[C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH2:16])[C:10]=3[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:18]=3)=[CH:8]2)[CH2:4]1.[CH3:31][N:32]=[C:33]=[O:34]>>[NH2:16][C:15]1[C:10]2[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:18]=3)=[CH:8][N:7]([C@@H:5]3[CH2:4][C@H:3]([CH2:2][NH:1][C:33]([NH:32][CH3:31])=[O:34])[CH2:6]3)[C:11]=2[N:12]=[CH:13][N:14]=1

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 178511294HCID 178511294, compound

Product 1

HCID 178485928HCID 178485928, compound

Procedure

cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-methyl-urea is prepared as described in Example 26 starting with cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and methyl isocyanate (ChemService Inc., West Chester, Pa., U.S.A.). Analytical HPLC: tR=6.49 min (Grad 2); ES-MS: m/eo=456.9.

Sources & evidence

ORD record: ord-f0c2e55350a2438ebca6f6980767e20f
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07326699B2

Reaction notes

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