N-bromobutanimide → HCID 178501312, compound

Participants

Reaction Steps

The title compound is prepared in analogy to Example 103 starting from 12.9 g (30.11 mmol) cis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester (see Step 3.1 above) and 6.07 g (33.12 mmol) N-bromosuccinimide in 250 ml dry N,N-dimethylformamide. After work-up, the raw material is purified by chromatography on silicagel (solvent: hexane-ethyl acetate 1:1). Analytical HPLC: tR=11.85 min (Grad 1); ES-MS: m/eo=506.9 and 509.9; NMR (DMSO-d6): 8.14/s (1H), 7.3-7.5/several m's (6H), 7.09/“d” (1H); 7.05/s (1H); 6.98/“d” (1H); 5.5-6.5/b (NH2); 5.13/s (2H); 5.11/m (1H); 3.66/s (3H); 3.35-3.5/m (2H); 3.08/m (1H); 2.58-2.7/m (2H).

Provenance & Evidence