Aluminium lithium hydride → HCID 178435368, compound

Participants

Reaction Steps

In analogy to Example 105, 0.49 g (1.09 mmol) trans-3-[4-amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester of Example 123 are reduced with 46 mg (1.18 mmol) lithium aluminiumhydride in THF. Reaction time: 17 h at 0-5° C. Analytical HPLC: tR=10.91 min (Grad 1); ES-MS: m/eo=429.1; NMR (DMSO-d6): 8.13/s (1H); 7.3-7.6/several m's (6H), 7.061/“d” (1H); 6.95/s (1H); 6.90/“d” (1H); 5.4-6.0/b (NH2); 5.15/s (2H); 4.93/m (1H); 4.681/“t” (OH); 3.60/m (2H); ca. 3.3-3.4/m (2H); 2.95/q (2H); 2.20/m (2H); 2.24/m (1H); 1.05/t (3H).

Provenance & Evidence