HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → 4-[[4-(4-Pyridinyl)phenyl]methyl]-2-thiazolamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| Reactant | 1-Bromo-3-(4-bromophenyl)propan-2-one | HCID 23404120 | — |
| Reactant | 4-[(4-Bromophenyl)methyl]-1,3-thiazol-2-amine | HCID 43260411 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[[4-(4-Pyridinyl)phenyl]methyl]-2-thiazolamine | HCID 58930770 | — |
Reaction Steps
In a similar manner to Preparation 6, step 3, the Suzuki coupling reaction of pyridine-4-yl boronic acid and 4-(4-bromo-benzyl)-thiazol-2-ylamine, was prepared via reaction of 1-bromo-3-(4-bromo-phenyl)-propan-2-one and thiourea in ethyl alcohol according to the procedure described in Preparation 1, step 2, gave the title compound 7. LC/MS m/z 268.08 (M+H)+; HPLC Rt: 0.598 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326728B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-5260b3b51bf646e1bbcef70729fc97f2 |
| Source note | uspto-grants-2008_02 |