HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2053076Generated: October 30, 2026
Dimethylformamide → 4-[4-(2-Tert-butyloxycarbonylethyl)-piperazin-1-yl]-6-(3-trifluoromethyl-phenyl)pyrimidine-2-carbonitrile
https://huagongshe.com/reaction/2053076
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | tert-Butyl acrylate | HCID 15458 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-(Piperazin-1-yl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile trifluoroacetic acid salt | HCID 86612495 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[4-(2-Tert-butyloxycarbonylethyl)-piperazin-1-yl]-6-(3-trifluoromethyl-phenyl)pyrimidine-2-carbonitrile | HCID 58878068 | — |
Reaction Steps
4-(Piperazin-1-yl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile trifluoroacetic acid salt (112 mg), tert-butyl acrylate (49 μl), diisopropylethylamine (59 μl) and dimethylformamide (0.2 ml) were combined and stirred at 45° C. for 16 hrs. After adding methanol, product was purified by using the prep-HPLC to generate 4-[4-(2-tert-butoxycarbonyl-ethyl)-piperazin-1-yl]-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile trifluoroacetic acid salt as a white solid (30 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07326715B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-538cbb0dfe2b4e76a435866140a551a8 |
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| Source note | uspto-grants-2008_02 |
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