Triethylamine → 2-[[6-Chloro-2-(methylthio)-4-pyrimidinyl]amino]ethanol

Participants

Reaction Steps

To the solution of 4,6-dichloro-2-methylsulfanylpyrimidine (9.75 g) in methanol (150 ml) was added aminoethanol (3.1 g) and triethylamine (7.5 ml). The mixture was stirred at room temperature for 20 hrs. After removal of solvent under vacuo, the residue was dissolved in isopropanol (15 ml) and ether (30 ml) was then added. The product was collected by filtration.

Provenance & Evidence