Ammonia → HCID 178513829, compound

HRID 2053096Notes

Reaction equation

HRID 2053096 reaction equation
C[O:2][C:3]([C:5]1[N:10]=[C:9]([OH:11])[CH:8]=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:6]=1)=O.[NH3:22]>>[OH:11][C:9]1[CH:8]=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:6]=[C:5]([C:3]([NH2:22])=[O:2])[N:10]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178499130HCID 178499130, compound

Product 1

HCID 178513829HCID 178513829, compound

Procedure

4-Hydroxy-6-(3-trifluoromethylphenyl)-pyrimidine-2-carboxylic acid methyl ester (17 mg) was stirred for one hour at room temperature in aqueous ammonia (500 ul). Solvent was evaporated under reduced pressure to yield product 4-hydroxy-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carboxylic acid amide (17 mg) as a white solid. 1H NMR (DMSO): δ 8.66 (s, 1H), 8.61 (s, 1H), 8.54 (d, 1H), 8.13 (s, 1H), 7.87 (d, 1H), 7.73 (t, 1H), 7.22 (s, 1H).

Workup

  1. customSolvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b985de625c954174a4f6f1a3f5e1784a
Source dataset
uspto-grants-2008_02
Patent number
US07326715B2

Reaction notes

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