Methanol → Methyl 3-aminophenylacetate

HRID 2053112Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH3:12]O>>[CH3:12][O:10][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([NH2:1])[CH:3]=1

Participants

Reactant 2

HCID 887Methanol

HCID 571807(3-Aminophenyl)acetic acid

Product 1

HCID 13054266Methyl 3-aminophenylacetateYield 77%

Procedure

3-Aminophenylacetic acid (5 g, 33.1 mmol) was esterified with MeOH using Method B to give the title compound Yield: 4.22 g, 77%; LC/MS tr 0.70 min; MS(ES+) m/z 166 (M+H)

Sources & evidence

ORD record: ord-4c962bae75cf423cb009e14f8bb820b6
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07326732B2

Reaction notes

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