3,5-Dichlorophenylboronic acid → (3-{[5-(3,5-Dichloro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acetic acid methyl ester

Participants

Reaction Steps

Methyl ester (16) (100 mg, 0.30 mmol) was coupled to 3,5-dichloro-phenylboronic acid (61 mg, 0.33 mmol) using Method E. The crude compound was purified by column chromatography, eluting in 17% EtOAc in heptane to give the title compound. Yield: 11 mg, 9%; LC/MS tr 1.76 min; MS(ES+) m/z 404, 406 (M+H)

Provenance & Evidence