HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Fluorophenyl)furan-2-carboxylic acid → (3-{[5-(4-Fluoro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Fluorophenyl)furan-2-carboxylic acid | HCID 738991 | — |
| Reactant | Ethyl 2-(3-aminophenyl)acetate | HCID 13042040 | — |
| Product | (3-{[5-(4-Fluoro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acetic acid ethyl ester | HCID 59654835 | — |
Reaction Steps
(3-Amino-phenyl)-acetic acid ethyl ester (44 mg, 0.24 mmol) was coupled to 5-(4-fluoro-phenyl)-furan-2-carboxylic acid (76) (50 mg, 0.24 mmol) using Method C. The crude compound was purified by column chromatography, eluting in 20% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326732B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-49334227619a447ca5489af75758231f |
| Source note | uspto-grants-2008_02 |