HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2053143Generated: October 25, 2026
Phenylboronic Acid → (3-[(4-Chloro-biphenyl-3-carbonyl)-amino]-phenyl)-acetic acid ethyl ester
https://huagongshe.com/reaction/2053143
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | [3-(5-Bromo-2-chlorobenzoylamino)phenyl]acetic acid ethyl ester | HCID 59654675 | — |
| Product | (3-[(4-Chloro-biphenyl-3-carbonyl)-amino]-phenyl)-acetic acid ethyl ester | HCID 59654748 | — |
Reaction Steps
[3-(5-Bromo-2-chloro-benzoylamino)-phenyl]-acetic acid ethyl ester (198 mg, 0.50 mmol) was coupled to phenylboronic acid using Method E, except that the reaction mixture was heated at 80° C. for 25 min. The crude product was purified by column chromatography using 20% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07326732B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-a58417df8caf4b50af8825d314ab4482 |
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| Source note | uspto-grants-2008_02 |
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