5-Phenylfuran-2-carboxylic acid → 3-{[(5-Phenyl-furan-2-carbonyl)-amino]-methyl}-benzoic acid methyl ester

HRID 2053167Notes

Reaction equation

HRID 2053167 reaction equation
[C:1]1([C:7]2[O:11][C:10]([C:12]([OH:14])=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:15][O:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][NH2:25])[CH:19]=1>>[CH3:15][O:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][NH:25][C:12]([C:10]2[O:11][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:8][CH:9]=2)=[O:14])[CH:19]=1

Participants

3

Reactant 2

HCID 7362555-Phenylfuran-2-carboxylic acidHCID 2794826Methyl 3-(aminomethyl)benzoate

Product 1

HCID 596548053-{[(5-Phenyl-furan-2-carbonyl)-amino]-methyl}-benzoic acid methyl ester

Procedure

5-Phenyl-furan-2-carboxylic acid (6) (17 mg, 0.10 mmol) was coupled to 3-aminomethyl-benzoic acid methyl ester (19.4 mg, 0.10 mmol) using Method D to give the title compound

Sources & evidence

ORD record
ord-5da252c18b644be6b791b89e7b15d0bf
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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