Methanol → Methyl 3-(3-aminophenyl)propanoate

HRID 2053170Notes

Reaction equation

HRID 2053170 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1.[CH3:13]O>>[CH3:13][O:11][C:10](=[O:12])[CH2:9][CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([NH2:1])[CH:3]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 27354063-(3-Aminophenyl)propionic acid

Product 1

HCID 10442275Methyl 3-(3-aminophenyl)propanoate

Procedure

3-(3-Amino-phenyl)-propionic acid (495 mg, 3 mmol) was esterified with MeOH using Method A, except that the residue was partitioned between EtOAc (10 ml) and saturated aqueous NaHCO3 (10 ml). The organic layer was dried (MgSO4), filtered and evaporated in vacuo to give the title compound.

Workup

  1. customwas partitioned between EtOAc (10 ml) and saturated aqueous NaHCO3 (10 ml)
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-1d6eda6724c2475da51361f416653bac
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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