5-Bromo-2-furanecarboxylic acid → 5-(3-Chlorophenyl)furan-2-carboxylic acid

HRID 2053175Notes

Reaction equation

HRID 2053175 reaction equation
Br[C:2]1[O:6][C:5]([C:7]([OH:9])=[O:8])=[CH:4][CH:3]=1.[Cl:10][C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[CH:15][CH:16]=1>>[Cl:10][C:11]1[CH:16]=[C:15]([C:2]2[O:6][C:5]([C:7]([OH:9])=[O:8])=[CH:4][CH:3]=2)[CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 685115-Bromo-2-furanecarboxylic acidHCID 2734323(3-Chlorophenyl)boronic acid

Product 1

HCID 7362565-(3-Chlorophenyl)furan-2-carboxylic acid

Procedure

5-Bromo-2-furoic acid (1 g, 5.8 mmol) was coupled to 3-chloro-phenylboronic acid (683 g, 4.4 mmol) acid using Method F to give the title compound.

Sources & evidence

ORD record
ord-676d42cfd6064b4d8a8a6c52c3d1ca2d
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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