5-Bromo-2-furanecarboxylic acid → 5-(3,5-Dichlorophenyl)furan-2-carboxylic acid

HRID 2053177Notes

Reaction equation

HRID 2053177 reaction equation
Br[C:2]1[O:6][C:5]([C:7]([OH:9])=[O:8])=[CH:4][CH:3]=1.[Cl:10][C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[C:15]([Cl:17])[CH:16]=1>>[Cl:10][C:11]1[CH:12]=[C:13]([C:2]2[O:6][C:5]([C:7]([OH:9])=[O:8])=[CH:4][CH:3]=2)[CH:14]=[C:15]([Cl:17])[CH:16]=1

Participants

3

Reactant 2

HCID 685115-Bromo-2-furanecarboxylic acidHCID 27343313,5-Dichlorophenylboronic acid

Product 1

HCID 40663695-(3,5-Dichlorophenyl)furan-2-carboxylic acid

Procedure

5-Bromo-2-furoic acid (1 g, 4.8 mmol) was coupled to 3,5-dichloro-phenylboronic acid (833 g, 4.4 mmol) acid using Method F to give the title compound.

Sources & evidence

ORD record
ord-dc773a5f1ee94fe6b071713de0d9f9ff
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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