HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminocinnamic acid ethyl ester → 3-(3-{[5-(4-Fluoro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| Reactant | 5-(4-Fluorophenyl)furan-2-carboxylic acid | HCID 738991 | — |
| Product | 3-(3-{[5-(4-Fluoro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester | HCID 68497349 | — |
Reaction Steps
5-(4-Fluoro-phenyl)-furan-2-carboxylic acid (54 mg, 0.26 mmol) was coupled to ethyl ester (60) (50 mg, 0.26 mmol) using Method C. The crude residue was purified by column chromatography eluting with 10% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326732B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-58e3158e7d8048cf9fbf2a4803781397 |
| Source note | uspto-grants-2008_02 |